Associate Investigator
Address:
Uniservices House
Building 439
Level 3, Room 335
University of Auckland
70 Symonds Street
Auckland 1010
Charles' group's research is centred around understanding the basic science of communication that occurs in the brain. They achieve this by combining both the fields of 'Cell Patterning' and ‘Multi-Electrode-Arrays’(MEAs) which are concerned with arrangement, control and stimulation/recording of human brain cells on silicon chip. By applying novel biomaterial cell patterning approaches and laser ablative microsurgery they organise and prune cell networks to a high fidelity. This has enabled his group to create a transformative chip technology allowing for the construction of precise large-scale regular grid networks of human brain cells on chip, which are individually addressable, electrically and photonically, at the cellular level, such that communication can be mapped accurately from the single-cell level to large network scales. This platform technology will allow for the mapping of signal propagation in real neural networks from the single cell level through to large network scales. The novelty is that they organise the neural cells into regular grid arrays so that communication can be more effectively and repeatably studied. The technology aims to provide new knowledge into debilitating human neuropathologies such as epilepsy, stroke and brain cancer and to provide a silicon chip platform technology to facilitate broader neuroscientific discovery. This work has been funded by the Royal Society of New Zealand's Marsden Fund and the Health Research Council.
You do a lot of deconstruction, but from it you can reveal very powerful insights into the mechanisms and processes that make things behave in the way they do, in our case these are the fundamental workings of how networks of brain cells communicate.
Professor Charles Unsworth
Annual Report
May 9, 2022
Funding successes for our investigators and their research programmes during 2021. This funding enables our researchers and collaborators to continue their breakthrough research in advanced materials and nanotechnology.

Annual Report
May 6, 2022
Systems that blend biology with electronics could answer some big questions.
Annual Report
March 24, 2021
Funding successes for our investigators and their research programmes during 2020. This funding enables our researchers and collaborators to continue their breakthrough research in advanced materials and nanotechnology.
Annual Report
May 26, 2020
Funding successes for our investigators and their research programmes during 2019. This funding enables our researchers and collaborators to continue their breakthrough research in advanced materials and nanotechnology.
Annual Report
April 8, 2019
This article from our 2018 Annual Report provides information about the range of awards received by MacDiarmid Institute Investigators over the past year.